Heart Valve Choice Site References:

Home Page

  1. Centers for Disease Control and Prevention. Valvular Heart Disease. https://www.cdc.gov/heartdisease/valvular_disease.htm. Accessed 04/27/2021.
  2. American Heart Association. Your Heart Valve Treatment Options. https://www.heart.org/en/health-topics/heart-valve-problems-and-disease/understanding-your-heart-valve-treatment-options. Accessed 05/04/2021.
  3. Data on file: Global Valve Market Assessment.
  4. Mayo Clinic. Common Causes for Aortic Valve Replacement. https://www.mayoclinic.org/tests-procedures/aortic-valve-repair-aortic-valve-replacement/about/pac-20385093. Accessed 05/04/2021.
  5. Mayo Clinic. Mitral Valve Stenosis Symptoms and Causes. https://www.mayoclinic.org/diseases-conditions/mitral-valve-stenosis/symptoms-causes/syc-20353159. Accessed 05/04/2021.
  6. Mayo Clinic. Mitral Valve Disease Regurgitation Symptoms and Causes. https://www.mayoclinic.org/diseases-conditions/mitral-valve-regurgitation/symptoms-causes/syc-20350178. Accessed 05/04/2021.

 

Know the Facts

 

Valve Durability 

  1. Rodriguez-Gabella T, et al. J Am Coll Cardiol 2017;70(8):1013-28. 
  2. Data on file: Lifetime of On-X Valve Study.
  3. Wang M, et al. Ann Thorac Surg 2017;104:1080-7. 
  4. Kaneko T, et al. J Thorac Cardiovasc Surg 2014; 147:117-26. 
  5. Dvir D, et al. Circulation 2018;137:388-99. 

 

Reoperation vs. Blood Thinner 

  1. Data on file: Lifetime of On-X Valve Study. 
  2. David TE, et al. Ann Thorac Surg 2010;90:775– 81. 
  3. Rodriguez-Gabella T, et al. J Am Coll Cardiol 2018;71(13):1401-12. 
  4. Nishimura RA, et al. J Am Coll Cardiol 2017;70:252-89. 
  5. Briffa N and Chambers J. Circulation 2017;135:1101–3. 
  6. Forcillo J, et al. Ann Thorac Surg. 2014;97:1526–32. 
  7. Chakravarty T, et al. J Am Coll Cardiol 2019;74(9):1190-200. 
  8. Otto CM, et al. Circulation. 2021;143: doi: 10.1161/CIR.0000000000000923. 
  9. Gerdisch MW, et al. J Thorac Cardiovasc Surg (2024), doi: https://doi.org/10.1016/j.jtcvs.2024.04.017.

 

Life Expectancy 

  1. Bourguignon T, et al. Ann Thorac Surg 2015;99(3):831-37. 
  2. Glaser N, et al. Euro Heart J 2016;37:2658-67. 
  3. Goldstone AB, et al. New Engl J. Med 2017;377:1847-57. 
  4. Otto CM, et al. Circulation 2021;143: doi: 10.1161/CIR.0000000000000923. 

 

Why On-X 

  1. On-X Prosthetic Heart Valve Instructions for Use. https://www.onxlti.com/ifu/.
  2. B.Z. Gao, N. Hosein, et al. ASAIO Journal 1997;43;5: 396-401.
  3. Rodriguez-Gabella T, et al. J Am Coll Cardiol 2017;70(8):1013-28.
  4. J.L. Ely et al. J Heart Valve Dis 1998;7(6): 626-632.
  5. Glaser N et al., Euro Heart J. 2016;37:2658-67.
  6. Kytö V, et al. The Annals of Thoracic Surgery (2019). https://doi.org/10.1016/j.athoracsur.2019.10.027.
  7. Diaz R, et al. J Thorac Cardiovasc Surg 2018;158(3):706-14.
  8. Goldstone AB et al; New Engl J. Med;2017:377:1847-57.
  9. Data on file (Lifetime of On-X Valve Study).
  10. Gerdisch MW, et al. J Thorac Cardiovasc Surg (2024), doi: https://doi.org/10.1016/j.jtcvs.2024.04.017.
  11. Otto CM, et al. Circulation. 2021;143: doi: 10.1161/CIR.0000000000000923.
  12. MedlinePlus. Normal INR Levels. https://medlineplus.gov/ency/article/003652.htm.
  13. ClinicalTrials.gov PROACT Xa Study. https://www.clinicaltrials.gov/ct2/show/NCT04142658?term=PROACT+Xa&draw=2&rank=1
  14. Granger C. et al. N Engl J Med 2011; 365:981-992 DOI: 10.1056/NEJMoa1107039.
  15. ClinicalTrials.gov PROACT MITRAL. https://clinicaltrials.gov/ct2/show/NCT00291525?term=proact&spons=on-x&draw=2&rank=1.

  16. Chu M.W.A., et al. (2023). Low-Dose Vs Standard Warfarin After Mechanical Mitral Valve Replacement: A Randomized Trial. Ann Thorac Surg., S0003-4975 (23)00005-X.